{"id":"1435","title":[{"locale":"en_US","setting_value":"Morphological Characteristics of the Lung during Lipopolysaccharide and Perfluorane Inhalation"},{"locale":"ru_RU","setting_value":"\u041c\u041e\u0420\u0424\u041e\u041b\u041e\u0413\u0418\u0427\u0415\u0421\u041a\u0410\u042f \u0425\u0410\u0420\u0410\u041a\u0422\u0415\u0420\u0418\u0421\u0422\u0418\u041a\u0410 \u041b\u0415\u0413\u041a\u0418\u0425 \u041f\u0420\u0418 \u0418\u041d\u0413\u0410\u041b\u042f\u0426\u0418\u0418 \u041b\u0418\u041f\u041e\u041f\u041e\u041b\u0418\u0421\u0410\u0425\u0410\u0420\u0418\u0414\u0410 \u0418 \u041f\u0415\u0420\u0424\u0422\u041e\u0420\u0410\u041d\u0410"}],"authors":[{"id":"5804","name":[{"setting_value":"  ","locale":""},{"setting_value":"Golubev A. M.","locale":"en_US"},{"setting_value":"\u0413\u043e\u043b\u0443\u0431\u0435\u0432 \u0410. \u041c.","locale":"ru_RU"}],"affiliation":{"":{"setting_value":null,"locale":""},"en_US":{"setting_value":"V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia 25, Petrovka, Build. 2, Moscow 107031","locale":"en_US"},"ru_RU":{"setting_value":"\u041d\u0418\u0418 \u043e\u0431\u0449\u0435\u0438\u0306 \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438\u043c. \u0412. \u0410. \u041d\u0435\u0433\u043e\u0432\u0441\u043a\u043e\u0433\u043e, \u041c\u043e\u0441\u043a\u0432\u0430, \u0420\u043e\u0441\u0441\u0438\u044f 107031, \u041c\u043e\u0441\u043a\u0432\u0430, \u0443\u043b. \u041f\u0435\u0442\u0440\u043e\u0432\u043a\u0430, \u0434. 25, \u0441\u0442\u0440. 2","locale":"ru_RU"}}},{"id":"5805","name":[{"setting_value":"  ","locale":""},{"setting_value":"Kuzovlev A. N.","locale":"en_US"},{"setting_value":"\u041a\u0443\u0437\u043e\u0432\u043b\u0435\u0432 \u0410. \u041d.","locale":"ru_RU"}],"affiliation":{"":{"setting_value":null,"locale":""},"en_US":{"setting_value":"V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia 25, Petrovka, Build. 2, Moscow 107031","locale":"en_US"},"ru_RU":{"setting_value":"\u041d\u0418\u0418 \u043e\u0431\u0449\u0435\u0438\u0306 \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438\u043c. \u0412. \u0410. \u041d\u0435\u0433\u043e\u0432\u0441\u043a\u043e\u0433\u043e, \u041c\u043e\u0441\u043a\u0432\u0430, \u0420\u043e\u0441\u0441\u0438\u044f 107031, \u041c\u043e\u0441\u043a\u0432\u0430, \u0443\u043b. \u041f\u0435\u0442\u0440\u043e\u0432\u043a\u0430, \u0434. 25, \u0441\u0442\u0440. 2","locale":"ru_RU"}}},{"id":"5806","name":[{"setting_value":"  ","locale":""},{"setting_value":"Sundukov D. V.","locale":"en_US"},{"setting_value":"\u0421\u0443\u043d\u0434\u0443\u043a\u043e\u0432 \u0414. \u0412.","locale":"ru_RU"}],"affiliation":{"":{"setting_value":null,"locale":""},"en_US":{"setting_value":"Peoples' Friendship University of Russia, Moscow, Russia 6, Miklukho","locale":"en_US"},"ru_RU":{"setting_value":"\u0420\u043e\u0441\u0441\u0438\u0438\u0306\u0441\u043a\u0438\u0438\u0306 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0434\u0440\u0443\u0436\u0431\u044b \u043d\u0430\u0440\u043e\u0434\u043e\u0432, \u041c\u043e\u0441\u043a\u0432\u0430, \u0420\u043e\u0441\u0441\u0438\u044f 117198, \u041c\u043e\u0441\u043a\u0432\u0430, \u0443\u043b. \u041c\u0438\u043a\u043b\u0443\u0445\u043e","locale":"ru_RU"}}},{"id":"5807","name":[{"setting_value":"  ","locale":""},{"setting_value":"Golubev M. A.","locale":"en_US"},{"setting_value":"\u0413\u043e\u043b\u0443\u0431\u0435\u0432 \u041c. \u0410.","locale":"ru_RU"}],"affiliation":{"":{"setting_value":null,"locale":""},"en_US":{"setting_value":"Peoples' Friendship University of Russia, Moscow, Russia 6, Miklukho","locale":"en_US"},"ru_RU":{"setting_value":"\u0420\u043e\u0441\u0441\u0438\u0438\u0306\u0441\u043a\u0438\u0438\u0306 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0434\u0440\u0443\u0436\u0431\u044b \u043d\u0430\u0440\u043e\u0434\u043e\u0432, \u041c\u043e\u0441\u043a\u0432\u0430, \u0420\u043e\u0441\u0441\u0438\u044f 117198, \u041c\u043e\u0441\u043a\u0432\u0430, \u0443\u043b. \u041c\u0438\u043a\u043b\u0443\u0445\u043e","locale":"ru_RU"}}}],"files":[{"locale":"ru_RU","url":"\/index.php\/rmt\/article\/viewFile\/1435\/890"},{"locale":"en_US","url":"\/index.php\/rmt\/article\/viewFile\/1435\/889"}],"pages":"6-13","authors_short":[{"locale":"","setting_value":"  ,   ,   ,   "},{"locale":"en_US","setting_value":"Golubev A. M., Kuzovlev A. N., Sundukov D. V., Golubev M. A."},{"locale":"ru_RU","setting_value":"\u0413\u043e\u043b\u0443\u0431\u0435\u0432 \u0410. \u041c., \u041a\u0443\u0437\u043e\u0432\u043b\u0435\u0432 \u0410. \u041d., \u0421\u0443\u043d\u0434\u0443\u043a\u043e\u0432 \u0414. \u0412., \u0413\u043e\u043b\u0443\u0431\u0435\u0432 \u041c. \u0410."}],"abstract":[{"locale":"en_US","setting_value":"<div class=\"page\" title=\"Page 1\"><div class=\"layoutArea\"><div class=\"column\"><p class=\"p1\"><span class=\"s1\">The use of perfluorane for the cytoprotection of lung structures in gram<\/span><span class=\"s2\">-<\/span><span class=\"s1\">negative lung infections has been inadequately studied. <em>Objective: <\/em>to experimentally reveal the pattern of morphological changes in the lung during combined inhalation of lipopolysaccharide (LPS) and perfluorane that has cytoprotective properties. <em>Materials and methods. <\/em>The experiment was carried out on 35 outbred male albino rats weighing 320\u2014350 g. The experimental animals were allocated to groups: 1) one<\/span><span class=\"s2\">-<\/span><span class=\"s1\">hour ventilation (controls) (<em>n<\/em>=5); 2) inhaled LPS 1.0 mg (<em>n<\/em>=10); 3) inhaled perfluorane 1.0 ml (<em>n<\/em>=10); 4) inhaled LPS 1.0 mg and then inhaled perfluorane 1.0 ml (<em>n<\/em>=10). <em>Results<\/em>. According to morphological findings, Group 1 (controls) was found to have no signs of lung structural changes. Group 2 (inhaled LPS) was noted to have signs of characteristic LPS<\/span><span class=\"s2\">-<\/span><span class=\"s1\">induced lung injury. Group 3 (inhaled perfluorane) showed complexes of macrophages with vacuolated cytoplasm (perfluorophages) in the bronchial lumen 3 hours after inhaled perfluorane administration. In Group 4, inhaled perfluorane exerted a cytoprotective effect: the degree of LPS<\/span><span class=\"s2\">-<\/span><span class=\"s1\"> induced morphological changes in the lung was much lower than that in Group 2. <em>Conclusion<\/em>. The experimental model of LPS<\/span><span class=\"s2\">-<\/span><span class=\"s1\">induced lung injury indicated that LPS inhalation led to alveolar and bronchial epithelial damage, interstitial and alveolar edema, and obvious cell infiltration at the expense of lymphocytes, segmented leukocytes, and macrophages. This model showed that inhaled perfluorane reduced the signs of alveolar and bronchial epithelial damage and the degree of interstitial and alveolar edema. This supports clinical findings and offers possibilities of using inhaled perfluorane in resuscitation.\u00a0<\/span><\/p><p class=\"p2\">\u00a0<\/p><\/div><\/div><\/div>"},{"locale":"ru_RU","setting_value":"<div class=\"page\" title=\"Page 1\"><div class=\"layoutArea\"><div class=\"column\"><p class=\"p1\"><span class=\"s1\">\u0418\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u043f\u0435\u0440\u0444\u0442\u043e\u0440\u0430\u043d\u0430 \u0441 \u0446\u0435\u043b\u044c\u044e \u0446\u0438\u0442\u043e\u043f\u0440\u043e\u0442\u0435\u043a\u0446\u0438\u0438 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440 \u043b\u0435\u0433\u043a\u0438\u0445 \u043f\u0440\u0438 \u0433\u0440\u0430\u043c\u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u0445 \u043b\u0435\u0433\u043a\u0438\u0445 \u0438\u0437\u0443<\/span><span class=\"s1\">\u0447\u0435\u043d\u043e \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e. <em>\u0426\u0435\u043b\u044c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f <\/em>\u2014 \u0432\u044b\u044f\u0432\u0438\u0442\u044c \u0432 \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440 \u043c\u043e\u0440\u0444\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0438\u0306 \u0432 \u043b\u0435\u0433\u043a\u0438\u0445 \u043f\u0440\u0438 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u043d\u043e\u043c \u0438\u043d\u0433\u0430\u043b\u044f\u0446\u0438\u043e\u043d\u043d\u043e\u043c \u0432\u043e\u0437\u0434\u0435\u0438\u0306\u0441\u0442\u0432\u0438\u0438 \u043b\u0438\u043f\u043e\u043f\u043e\u043b\u0438\u0441\u0430\u0445\u0430\u0440\u0438\u0434\u0430 (\u041b\u041f\u0421) \u0438 \u043f\u0435\u0440\u0444\u0442\u043e\u0440\u0430\u043d\u0430, \u043e\u0431\u043b\u0430\u0434\u0430\u044e\u0449\u0435\u0433\u043e \u0446\u0438\u0442\u043e\u043f\u0440\u043e\u0442\u0435\u043a\u0442\u043e\u0440<\/span><span class=\"s1\">\u043d\u044b\u043c\u0438 \u0441\u0432\u043e\u0438\u0306\u0441\u0442\u0432\u0430\u043c\u0438. <em>\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u044b \u0438 \u043c\u0435\u0442\u043e\u0434\u044b. <\/em>\u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442 \u0431\u044b\u043b \u0432\u044b\u043f\u043e\u043b\u043d\u0435\u043d \u043d\u0430 48 \u0431\u0435\u043b\u044b\u0445 \u0431\u0435\u0441\u043f\u043e\u0440\u043e\u0434\u043d\u044b\u0445 \u043a\u0440\u044b\u0441\u0430\u0445<\/span><span class=\"s2\">-<\/span><span class=\"s1\">\u0441\u0430\u043c\u0446\u0430\u0445 \u043c\u0430\u0441<\/span><span class=\"s1\">\u0441\u043e\u0438\u0306 320\u2014350 \u0433. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0435 \u0436\u0438\u0432\u043e\u0442\u043d\u044b\u0435 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\u0431\u0440\u043e\u043d<\/span><span class=\"s1\">\u0445\u043e\u0432 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442\u0441\u044f \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u044b \u043c\u0430\u043a\u0440\u043e\u0444\u0430\u0433\u043e\u0432 \u0441 \u0432\u0430\u043a\u0443\u043e\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0438\u0306 \u0446\u0438\u0442\u043e\u043f\u043b\u0430\u0437\u043c\u043e\u0438\u0306 (\u043f\u0435\u0440\u0444\u0442\u043e\u0440\u043e\u0444\u0430\u0433\u0438). \u0412 \u0413\u0440. 4 \u0438\u043d\u0433\u0430\u043b\u044f\u0446\u0438<\/span><span class=\"s1\">\u043e\u043d\u043d\u043e\u0435 \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u0435 \u043f\u0435\u0440\u0444\u0442\u043e\u0440\u0430\u043d\u0430 \u043e\u043a\u0430\u0437\u044b\u0432\u0430\u0435\u0442 \u0446\u0438\u0442\u043e\u043f\u0440\u043e\u0442\u0435\u043a\u0442\u043e\u0440\u043d\u044b\u0438\u0306 \u044d\u0444\u0444\u0435\u043a\u0442: \u0441\u0442\u0435\u043f\u0435\u043d\u044c \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u043c\u043e\u0440\u0444\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0438\u0437\u043c\u0435\u043d\u0435<\/span><span class=\"s1\">\u043d\u0438\u0438\u0306 \u0432 \u043b\u0435\u0433\u043a\u0438\u0445, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u044b\u0445 \u041b\u041f\u0421, \u0431\u044b\u043b\u0430 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u043c\u0435\u043d\u044c\u0448\u0435 \u043f\u043e\u0441\u043b\u0435 \u0438\u043d\u0433\u0430\u043b\u044f\u0446\u0438\u0438 \u043f\u0435\u0440\u0444\u0442\u043e\u0440\u0430\u043d\u0430 \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u0413\u0440. 2. <em>\u0412\u044b\u0432\u043e\u0434\u044b<\/em>. \u0412 \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u043e\u0438\u0306 \u043c\u043e\u0434\u0435\u043b\u0438 \u041b\u041f\u0421<\/span><span class=\"s2\">-<\/span><span class=\"s1\">\u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f \u043b\u0435\u0433\u043a\u0438\u0445 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u043e, \u0447\u0442\u043e \u0438\u043d\u0433\u0430\u043b\u044f\u0446\u0438\u044f \u041b\u041f\u0421 \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044e \u0430\u043b\u044c\u0432\u0435\u043e\u043b\u044f\u0440\u043d\u043e\u0433\u043e \u0438 \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u044f, \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044e \u0438\u043d\u0442\u0435\u0440\u0441\u0442\u0438\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0438 \u0430\u043b\u044c\u0432\u0435\u043e\u043b\u044f\u0440\u043d\u043e\u0433\u043e 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\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438\u0306 \u0438 \u043e\u0442\u043a\u0440\u044b\u0432\u0430\u0435\u0442 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0434\u043b\u044f \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0438\u043d\u0433\u0430\u043b\u044f\u0446\u0438\u0438 \u043f\u0435\u0440\u0444\u0442\u043e\u0440\u0430\u043d\u0430 \u0432 \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438.\u00a0<\/span><\/p><\/div><\/div><\/div>"}],"keywords":[{"locale":"en_US","setting_value":["critical conditions","lipopolysaccharide-induced lung injuries","perfluorane","cytoprotection"]},{"locale":"ru_RU","setting_value":[]}],"doi":"10.15360\/1813-9779-2015-1-6-13","url":"\/rmt\/article\/view\/1435","citations":[{"locale":"ru_RU","setting_value":["1. \u041c\u043e\u0440\u043e\u0437 \u0412.\u0412., \u0413\u043e\u043b\u0443\u0431\u0435\u0432 \u0410.\u041c., \u041a\u0443\u0437\u043e\u0432\u043b\u0435\u0432 \u0410.\u041d., \u041f\u0438\u0441\u0430\u0440\u0435\u0432 \u0412.\u041c., \u0428\u0430\u0431\u0430\u043d\u043e\u0432 \u0410.\u041a., \u0413\u043e\u043b\u0443\u0431\u0435\u0432 \u041c.\u0410. \u0421\u0443\u0440\u0444\u0430\u043a\u0442\u0430\u043d\u0442\u043d\u044b\u0438\u0306 \u043f\u0440\u043e\u0442\u0435\u0438\u043d D \u2013 \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440 \u043e\u0441\u0442\u0440\u043e\u0433\u043e \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u0434\u0438\u0441\u0442\u0440\u0435\u0441\u0441-\u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430. \u041e\u0431\u0449\u0430\u044f \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2013; 9 (4): 11\u201417. http:\/\/dx.doi.org\/10.15360\/1813-9779-2013-4-11","2. \u0425\u0443\u0431\u0443\u0442\u0438\u044f \u041c.\u0428., \u0428\u0430\u0431\u0430\u043d\u043e\u0432 \u0410.\u041a., \u0411\u0443\u043b\u0430\u0432\u0430 \u0413.\u0412., \u0414\u043e\u0440\u0444\u043c\u0430\u043d \u0410.\u0413., \u0417\u0430\u0438\u0306\u043d\u0443\u0434\u0438\u043d\u043e\u0432 \u0417.\u041c., \u0421\u043a\u0443\u043b\u0430\u0447\u0435\u0432 \u041c.\u0412., \u041a\u0443\u0437\u043e\u0432\u043b\u0435\u0432 \u0410.\u041d., \u0413\u0440\u0435\u0431\u0435\u043d\u0447\u0438\u043a\u043e\u0432 \u041e.\u0410., \u0421\u0435\u0440\u0433\u0435\u0435\u0432 \u0410.\u0410., \u0428\u043f\u0438\u0442\u043e\u043d\u043a\u043e\u0432 \u041c.\u0418., \u041c\u0430\u043b\u044c\u0446\u0435\u0432 \u0413.\u042e. \u041e\u043a\u0438\u0441\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0438\u0306 \u0434\u0438\u0441\u0442\u0440\u0435\u0441\u0441 \u0443 \u043f\u043e\u0441\u0442\u0440\u0430\u0434\u0430\u0432\u0448\u0438\u0445 \u0441 \u0442\u044f\u0436\u0435\u043b\u043e\u0438\u0306 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u043d\u043e\u0438\u0306 \u0442\u0440\u0430\u0432\u043c\u043e\u0438\u0306. \u041e\u0431\u0449\u0430\u044f \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2014; 10 (2): 23\u201430. http:\/\/dx.doi.org\/10.15360\/1813-9779-2014-2-23-30","3. \u042f\u043a\u043e\u0432\u043b\u0435\u0432 \u0410.\u042e., \u0413\u0443\u0449\u0438\u043d\u0430 \u041d.\u041d., \u041d\u0438\u044f\u0437\u043c\u0430\u0442\u043e\u0432 \u0410.\u0410., \u0417\u0430\u0438\u0306\u0446\u0435\u0432 \u0420.\u041c., \u0413\u043e\u043b\u0443\u0431\u0446\u043e\u0432\u0430 \u0415.\u042e., \u0420\u044f\u0431\u0438\u043a\u043e\u0432\u0430 \u041c.\u0410. \u0420\u0430\u043d\u043d\u044f\u044f \u043e\u0446\u0435\u043d\u043a\u0430 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0430\u043d\u0442\u0438\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0438\u0306 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043d\u043e\u0437\u043e\u043a\u043e\u043c\u0438\u0430\u043b\u044c\u043d\u043e\u0438\u0306 \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0438 \u043f\u0443\u0442\u0435\u043c \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u043b\u0438\u043f\u043e\u043f\u043e\u043b\u0438\u0441\u0430\u0445\u0430\u0440\u0438\u0434\u0430. \u041e\u0431\u0449\u0430\u044f \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2013; 9 (6): 45\u201452. http:\/\/dx.doi.org\/10.15360\/1813-9779-2013-6-45","4. \u041c\u043e\u0440\u043e\u0437 \u0412.\u0412., \u0413\u043e\u043b\u0443\u0431\u0435\u0432 \u0410.\u041c., \u041c\u0430\u0440\u0447\u0435\u043d\u043a\u043e\u0432 \u042e.\u0412., \u0412\u043b\u0430\u0441\u0435\u043d\u043a\u043e \u0410.\u0412., \u041a\u0443\u0437\u043e\u0432\u043b\u0435\u0432 \u0410.\u041d. \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u043e\u0441\u0442\u0440\u043e\u0433\u043e \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u0434\u0438\u0441\u0442\u0440\u0435\u0441\u0441-\u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u043f\u0440\u0438 \u043d\u043e\u0437\u043e\u043a\u043e\u043c\u0438\u0430\u043b\u044c\u043d\u043e\u0438\u0306 \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0438. \u041c\u0435\u0442\u043e\u0434\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438. \u041c.: \u041d\u0418\u0418\u041e\u0420 \u0420\u0410\u041c\u041d; 2011.","5. \u041a\u0443\u0437\u043e\u0432\u043b\u0435\u0432 \u0410.\u041d., \u041c\u043e\u0440\u043e\u0437 \u0412.\u0412., \u0413\u043e\u043b\u0443\u0431\u0435\u0432 \u0410.\u041c., \u041f\u043e\u043b\u043e\u0432\u043d\u0438\u043a\u043e\u0432 \u0421.\u0413. \u0418\u043d\u0433\u0430\u043b\u044f\u0446\u0438\u043e\u043d\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0431\u0438\u043e\u0442\u0438\u043a\u0438 \u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0442\u044f\u0436\u0435\u043b\u043e\u0438\u0306 \u043d\u043e\u0437\u043e\u043a\u043e\u043c\u0438\u0430\u043b\u044c\u043d\u043e\u0438\u0306 \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0438. \u041e\u0431\u0449\u0430\u044f \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2013; 9 (6): 61\u201470. http:\/\/dx.doi.org\/10.15360\/1813-9779-2013-6-61","6. \u041c\u043e\u0440\u043e\u0437 \u0412.\u0412., \u0427\u0435\u0440\u043d\u044b\u0448 \u0410.\u041c., \u041a\u043e\u0437\u043b\u043e\u0432\u0430 \u0415.\u041a., \u0421\u0435\u0440\u0433\u0443\u043d\u043e\u0432\u0430 \u0412.\u0410., \u0413\u0443\u0434\u043a\u043e\u0432\u0430 \u041e.\u0415., \u0424\u0435\u0434\u043e\u0440\u043e\u0432\u0430 \u041c.\u0421., \u041a\u0438\u0440\u0441\u0430\u043d\u043e\u0432\u0430 \u0410.\u041a., \u041d\u043e\u0432\u043e\u0434\u0435\u0440\u0436\u043a\u0438\u043d\u0430 \u0418.\u0421. \u041d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u043d\u0430\u043d\u043e\u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u044b \u043c\u0435\u043c\u0431\u0440\u0430\u043d \u044d\u0440\u0438\u0442\u0440\u043e\u0446\u0438\u0442\u043e\u0432 \u043f\u0440\u0438 \u043e\u0441\u0442\u0440\u043e\u0438\u0306 \u043a\u0440\u043e\u0432\u043e\u043f\u043e\u0442\u0435\u0440\u0435 \u0438 \u0438\u0445 \u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u044f \u043f\u0435\u0440\u0444\u0442\u043e\u0440\u0443\u0433\u043b\u0435\u0440\u043e\u0434\u043d\u043e\u0438\u0306 \u044d\u043c\u0443\u043b\u044c\u0441\u0438\u0435\u0438\u0306. \u041e\u0431\u0449\u0430\u044f \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2011; 7 (2): 5\u20149. http:\/\/dx.doi.org\/10.15360\/1813-9779-2011-2-5 ","7. Sender V., Stamme C. Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization. Commun. Integr. Biol. 2014; 7: e29053. http:\/\/dx.doi.org\/10.4161\/cib.29053. PMID: 25136402 ","8. Hou S., Ding H., Ly Q., Yin X., Song J., Landen N.X., Fan H. Therapeutic effect of intravenous infusion of perfluorocarbon emulsion on LPS- induced acute lung injury. PLos One. 2014; 9 (1): e87826. http:\/\/dx.doi.org\/10.1371\/journal.pone.0087826. PMID: 24489970 ","9. Yuan Q., Jiang Y.W., Fang Q.H. Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats. APMIS. 2014; 122 (9): 810\u2014817. http:\/\/dx.doi.org\/10.1111\/apm.12222. PMID: 24484066 ","10. Zhao X.W., Zhang J.P., Wang X.G., Ma H.J., Xie J.H., Liu Y.N. Effects of aerosolized perfluorocarbon on gas exchange, respiratory mechanics and hemodynamics in a swine model of acute respiratory distress syndrome. Zhonghua Jie He He Hu Xi Za Zhi. 2006; 29 (2): 104\u2014108. PMID: 16677452 ","11. Wang X., Zhang J., Li X., Liu Y., Yang H., Zhao X., Xie L., Yin L. Sustained improvement of gas exchange and lung mechanics by vaporized perfluorocarbon inhalation in piglet acute lung injury model. Clin. Respir. J. 2014; 8 (2): 160\u2014166. http:\/\/dx.doi.org\/10.1111\/crj.12053. PMID: 24028088 ","12. \u041c\u043e\u0440\u043e\u0437 \u0412.\u0412., \u041e\u0441\u0442\u0430\u043f\u0447\u0435\u043d\u043a\u043e \u0414.\u0410., \u0412\u043b\u0430\u0441\u0435\u043d\u043a\u043e \u0410.\u0412., \u041e\u0441\u0438\u043f\u043e\u0432 \u041f.\u042e., \u0413\u0435\u0440\u0430\u0441\u0438\u043c\u043e\u0432 \u041b.\u0412. \u042d\u043d\u0434\u043e\u0442\u0440\u0430\u0445\u0435\u0430\u043b\u044c\u043d\u043e\u0435 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u043f\u0435\u0440\u0444\u0442\u043e\u0440\u0430\u043d\u0430 \u0432 \u0443\u0441\u043b\u043e\u0432\u0438\u044f\u0445 \u0418\u0412\u041b \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u043e\u0441\u0442\u0440\u044b\u043c \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u043c \u0434\u0438\u0441\u0442\u0440\u0435\u0441\u0441-\u0441\u0438\u043d\u0434\u0440\u043e\u043c\u043e\u043c. \u041e\u0431\u0449\u0430\u044f \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2005; 1 (2): 5\u201411. http:\/\/dx.doi.org\/10.15360\/1813-9779-2005-2-5-11 ","13. Nakstad B., Wolfson M.R., Shaffer T.H., K\u00e4hler H., Lindemann R., Fugelseth D., Lyberg T. Perfluorochemical liquids modulate cell-mediated inflammatory responses. Crit. Care Med. 2001; 29 (9): 1731\u20141737. http:\/\/dx.doi.org\/10.1097\/00003246-200109000-00013. PMID: 11546973 ","14. Koch T., Ragaller M., Haufe M., Hofer A., Grosser M., Albrecht D.M., Kotzsch M., Luther T. Perfluorohexane attenuates proinflammatory and procoagulatory response of activated monocytes and alveolar macrophages. Anesthesiology. 2001; 94 (1): 101\u2014109. http:\/\/dx.doi.org\/10.1097\/00000542-200101000-00020. PMID: 11135729 ","15. Thomassen M.J., Buhrow L.T., Wiedemann H.P. Perflubron decreases inflammatory cytokine production by human alveolar macrophages. Crit. Care Med. 1997; 25 (12): 2045\u20132047. http:\/\/dx.doi.org\/10.1097\/00003246-199712000-00023. PMID: 9403756 ","16. Gale S.C., Gorman G.D., Copeland J.G., McDonagh P.F. Perflubron emulsion prevents PMN activation and improves myocardial functional recovery after cold ischemia and reperfusion. J. Surg. Res. 2007; 138 (1): 135\u2013140. PMID: 17173933 ","17. Chang H., Kuo F.C., Lai Y.S., Chou T.C. Inhibition of inflammatory responses by FC-77, a perfluorochemical, in lipopolysaccharide-treated RAW 264.7 macrophages. Intensive Care Med. 2005; 31 (7): 977\u2013984. http:\/\/dx.doi.org\/10.1007\/s00134-005-2652-y. PMID: 15931525 ","18. Woods C.M., Neslund G., Kornbrust E., Flaim S.F. Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro. Am. J. Physiol. Lung Cell Mol. Physiol. 2000; 278 (5): L1008\u2013L1017. PMID: 10781432 ","19. Baba A., Kim Y.K., Zhang H., Liu M., Slutsky A.S. Perfluorocarbon blocks tumor necrosis factor-alpha-induced interleukin-8 release from alveolar epithelial cells in vitro. Crit. Care Med. 2000; 28 (4): 1113\u20131118. PMID: 10809292 ","20. Schoof E., von der Hardt K., Kandler M.A., Abendroth F., Papadopoulos T., Rascher W., D\u00f6tsch J. Aerosolized perfluorocarbon reduces adhesion molecule gene expression and neutrophil sequestration in acute respiratory distress. Eur. J. Pharmacol. 2002; 457 (2-3): 195\u2013200. http:\/\/dx.doi.org\/10.1016\/S0014-2999(02)02665-1. PMID: 12464366 "]},{"locale":"en_US","setting_value":["1. Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M., Shabanov A.K., Golubev M.A. Surfaktantnyi\u0306 protein D \u2013 biomarker ostrogo respiratornogo distress-sindroma. Obshchaya reanimatologiya. 2013; 9 (4): 11\u201417. http:\/\/dx.doi.org\/10.15360\/1813-9779-2013-4-11","2. Khubutiya M.Sh., Shabanov A.K., Bulava G.V., Dorfman A.G., Zai\u0306nudinov Z.M., Skulachev M.V., Kuzovlev A.N., Grebenchikov O.A., Sergeev A.A., Shpitonkov M.I., Mal'tsev G.Yu. Okislitel'nyi\u0306 distress u postradavshikh s tyazheloi\u0306 sochetannoi\u0306 travmoi\u0306. Obshchaya reanimatologiya. 2014; 10 (2): 23\u201430. http:\/\/dx.doi.org\/10.15360\/1813-9779-2014-2-23-30","3. Yakovlev A.Yu., Gushchina N.N., Niyazmatov A.A., Zai\u0306tsev R.M., Golubtsova E.Yu., Ryabikova M.A. Rannyaya otsenka effektivnosti antibakterial'noi\u0306 terapii nozokomial'noi\u0306 pnevmonii putem kolichestvennogo opredeleniya lipopolisakharida. Obshchaya reanimatologiya. 2013; 9 (6): 45\u201452. http:\/\/dx.doi.org\/10.15360\/1813-9779-2013-6-45","4. Moroz V.V., Golubev A.M., Marchenkov Yu.V., Vlasenko A.V., Kuzovlev A.N. Diagnostika ostrogo respiratornogo distress-sindroma pri nozokomial'noi\u0306 pnevmonii. Metodicheskie rekomendatsii. M.: NIIOR RAMN; 2011.","5. Kuzovlev A.N., Moroz V.V., Golubev A.M., Polovnikov S.G. Ingalyatsionnye antibiotiki v lechenii tyazheloi\u0306 nozokomial'noi\u0306 pnevmonii. Obshchaya reanimatologiya. 2013; 9 (6): 61\u201470. http:\/\/dx.doi.org\/10.15360\/1813-9779-2013-6-61","6. Moroz V.V., Chernysh A.M., Kozlova E.K., Sergunova V.A., Gudkova O.E., Fedorova M.S., Kirsanova A.K., Novoderzhkina I.S. Narusheniya nanostruktury membran eritrotsitov pri ostroi\u0306 krovopotere i ikh korrektsiya perftoruglerodnoi\u0306 emul'siei\u0306. Obshchaya reanimatologiya. 2011; 7 (2): 5\u20149. http:\/\/dx.doi.org\/10.15360\/1813-9779-2011-2-5 ","7. Sender V., Stamme C. Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization. Commun. Integr. Biol. 2014; 7: e29053. http:\/\/dx.doi.org\/10.4161\/cib.29053. PMID: 25136402 ","8. Hou S., Ding H., Ly Q., Yin X., Song J., Landen N.X., Fan H. Therapeutic effect of intravenous infusion of perfluorocarbon emulsion on LPS- induced acute lung injury. PLos One. 2014; 9 (1): e87826. http:\/\/dx.doi.org\/10.1371\/journal.pone.0087826. PMID: 24489970 ","9. Yuan Q., Jiang Y.W., Fang Q.H. Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats. APMIS. 2014; 122 (9): 810\u2014817. http:\/\/dx.doi.org\/10.1111\/apm.12222. PMID: 24484066 ","10. Zhao X.W., Zhang J.P., Wang X.G., Ma H.J., Xie J.H., Liu Y.N. Effects of aerosolized perfluorocarbon on gas exchange, respiratory mechanics and hemodynamics in a swine model of acute respiratory distress syndrome. Zhonghua Jie He He Hu Xi Za Zhi. 2006; 29 (2): 104\u2014108. PMID: 16677452 ","11. Wang X., Zhang J., Li X., Liu Y., Yang H., Zhao X., Xie L., Yin L. Sustained improvement of gas exchange and lung mechanics by vaporized perfluorocarbon inhalation in piglet acute lung injury model. Clin. Respir. J. 2014; 8 (2): 160\u2014166. http:\/\/dx.doi.org\/10.1111\/crj.12053. PMID: 24028088 ","12. Moroz V.V., Ostapchenko D.A., Vlasenko A.V., Osipov P.Yu., Gerasimov L.V. Endotrakheal'noe primenenie perftorana v usloviyakh IVL u bol'nykh s ostrym respiratornym distress-sindromom. Obshchaya reanimatologiya. 2005; 1 (2): 5\u201411. http:\/\/dx.doi.org\/10.15360\/1813-9779-2005-2-5-11 ","13. Nakstad B., Wolfson M.R., Shaffer T.H., K\u00e4hler H., Lindemann R., Fugelseth D., Lyberg T. Perfluorochemical liquids modulate cell-mediated inflammatory responses. Crit. Care Med. 2001; 29 (9): 1731\u20141737. http:\/\/dx.doi.org\/10.1097\/00003246-200109000-00013. PMID: 11546973 ","14. Koch T., Ragaller M., Haufe M., Hofer A., Grosser M., Albrecht D.M., Kotzsch M., Luther T. Perfluorohexane attenuates proinflammatory and procoagulatory response of activated monocytes and alveolar macrophages. Anesthesiology. 2001; 94 (1): 101\u2014109. http:\/\/dx.doi.org\/10.1097\/00000542-200101000-00020. PMID: 11135729 ","15. Thomassen M.J., Buhrow L.T., Wiedemann H.P. Perflubron decreases inflammatory cytokine production by human alveolar macrophages. Crit. Care Med. 1997; 25 (12): 2045\u20132047. http:\/\/dx.doi.org\/10.1097\/00003246-199712000-00023. PMID: 9403756 ","16. Gale S.C., Gorman G.D., Copeland J.G., McDonagh P.F. Perflubron emulsion prevents PMN activation and improves myocardial functional recovery after cold ischemia and reperfusion. J. Surg. Res. 2007; 138 (1): 135\u2013140. PMID: 17173933 ","17. Chang H., Kuo F.C., Lai Y.S., Chou T.C. Inhibition of inflammatory responses by FC-77, a perfluorochemical, in lipopolysaccharide-treated RAW 264.7 macrophages. Intensive Care Med. 2005; 31 (7): 977\u2013984. http:\/\/dx.doi.org\/10.1007\/s00134-005-2652-y. PMID: 15931525 ","18. Woods C.M., Neslund G., Kornbrust E., Flaim S.F. Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro. Am. J. Physiol. Lung Cell Mol. Physiol. 2000; 278 (5): L1008\u2013L1017. PMID: 10781432 ","19. Baba A., Kim Y.K., Zhang H., Liu M., Slutsky A.S. Perfluorocarbon blocks tumor necrosis factor-alpha-induced interleukin-8 release from alveolar epithelial cells in vitro. Crit. Care Med. 2000; 28 (4): 1113\u20131118. PMID: 10809292 ","20. Schoof E., von der Hardt K., Kandler M.A., Abendroth F., Papadopoulos T., Rascher W., D\u00f6tsch J. Aerosolized perfluorocarbon reduces adhesion molecule gene expression and neutrophil sequestration in acute respiratory distress. Eur. J. Pharmacol. 2002; 457 (2-3): 195\u2013200. http:\/\/dx.doi.org\/10.1016\/S0014-2999(02)02665-1. PMID: 12464366 "]}],"marked_citation":"","issue":{"id":112,"title":[{"locale":"en_US","setting_value":"2015-11-1"},{"locale":"ru_RU","setting_value":"2015-11-1"}],"fileName":[{"locale":"en_US","setting_value":"\/public\/journals\/1\/cover_issue_112_en_US.jpg"},{"locale":"ru_RU","setting_value":"\/public\/journals\/1\/cover_issue_112_ru_RU.jpg"}],"volume":"11","issue":"1","year":"2015"},"published":"2015-02-26 00:00:00","jTitle":[{"locale":"en_US","setting_value":"General Reanimatology"},{"locale":"ru_RU","setting_value":"\u041e\u0431\u0449\u0430\u044f \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f"}],"baseUrl":"http:\/\/rmt.elpub.ru\/"}